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A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)

that bone loss was most pronounced in weight-bearing skeletal sites, with no significant changes in non-weight-bearing areas such as the radius, suggests that mechanical unloading may be a key driver of bone resorption rather than a direct pharmacologic effect of GLP-1 receptor activation